One of my main research interests is the analysis of genetic factors that influence multiple sclerosis susceptibility as well as of genetic factors affecting the progression and treatment of MS. In 2016, we have published a large genome-wide association study on MS susceptibility in Germans. Currently, I am working on genetic factors influencing the development of neutralizing antibodies against interferon beta treatment. Further, still unpublished projects involve genetic factors influencing MRI parameters or vitamin D levels.

Psychiatric genetics is my second major research interest. Here, I am currently conducting projects analyzing MRI structural imaging genetics data as well as an analysis of families with a high prevalence of affective disorders.

Finally, I still find molecular neurogenetics and synaptic plasticity fascinating. After the characterization of a novel postsynaptic Drosophila gene important for learning and memory,  a new manuscript examining synaptic diversity in the Drosophila central nervous system has recently been accepted for publication.


You may view a talk on genetic factors influencing binding and neutralizing antibodies against interferon β treatment in multiple sclerosis patients, given on behalf of the Department of Neurology of the Technical University Munich and the ABIRISK consortium at the Mastering Immunity Europe 2018 meeting in Oxford: